The effect of soy protein containing soy isoflavones on serum concentration of cell adhesion molecules: A systematic review and meta-analysis of randomized controlled trials

• The overall effect revealed taking soy protein plus isoflavones could not reduce serum concentration of studied CAMs. Soy E-selectin in studies with sample size <84. VCAM-1 which participants’ age is ?55 years old. combination might the inflammatory mediators. In this study, we attempted to summarize combined on circulating E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell (VCAM-1) adults. Clinicaltrials.gov, Web Science, Cochrane Library, PubMed, Scopus were searched for English articles no time limit regarding publication up December 2020. Thereafter, mean changes from baseline their standard deviations (SDs) both intervention comparison groups used calculate size. We DerSimonian Laird random-effects model if heterogeneity test was statistically significant. Cochran's Q I-squared statistic also statistical effects. Eight found as eligible study. treatment duration between 6 24 weeks. dose a range 30–112 mg/day 11.25–52 g/day. Overall, supplements containing associated molecules, ICAM-1, or (WMD = 0.65, 95 % CI: -2.58, 3.89; p 0.692; WMD 2.68, -0.98, 6.34; 0.151; 2.66, -6.28, 11.61; 0.559, respectively). significantly levels VCAM-1. However, need more large participants different categories regard.